ABSTRACT
[Objective] To observe the effect of Naolisu Granules (NG) for experimental cerebral ischemia in rats. [Methods] Rat models with cerebral ischemia was set up by embolization of middle artery. To observe the effects of NG on cerebrovascular permeability, cerebral water content was examined and cerebral Evans blue (EB) content was detected with chromatometry. Meanwhile, the effect of HG on cerebral histological structure was observed with hematoxylin and eosin(HE) staining method. [Results] NG decreased cerebral capillary permeability and cerebral edema ( P
ABSTRACT
【Objective】 To investigate the effect of Fucongxiang Liquid (FL) on hippocampal CA1 neurons in rat models with vascular dementia. 【Methods】 Forty SD rots were randomized to four groups: pseudo-operation group, model group, Naofukang group and FL group. Rat models with vascular dementia were established by repeated cerebral ischemia/reperfusion combined with decreasing blood pressure and then were given with normal saline, Naofukang and FL respectively for 15 days. After treatment, the brain of mrs was taken out to make slices for hematoxylin and eosin staining to observe the histomorphological changes of hippocampal CA1 neurons. 【Results】 As compared with the pseudooperation group, a large amount of damaged, degenerative or even necrotic neurons were fotmd in the model group; FL and Naofukang could reduce the damage of neurons to different extents. 【Conclusion】 FL exerts a protective effect on hippocampal CA1 neurons in mice models with vascular dementia.
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Objective: To study therapeutic effect and mechanisms of inhalation of drug-oxygen Fuchong Xiangye for treatment of vascular dementia. Methods: 123 cases were randomly divided into treatment group and control group by single-blind. Thertapeutic effects, superoxide dismutase (SOD) activity in red cells, plasma lipid peroxide, triglyceride, serum cholesterol and high density lipid protein (HDL) levels, and electroencephalogram were investigated before and after treatment. Results: The improvement of symptom scores and the above indexes after treatment in the treatment group were more obvious than those in the control group, with no reserve reaction in both groups. Conclusion: Inhalation of drug-oxygen Fuchong Xiangye has a better therapeutic effect on vascular dementia, and the mechanism is related with decrease of blood lipid, and increase of HDL and SOD.